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CSF analysis for Clinical Chemists [1]
CSF analysis for Neurologists [2]
Neurologic CSF diagnostic [3,
16, 17]
Theoretical Aspects
Anatomy and Physiology of the CSF space [1,
2, 4,
5]
Biophysics of blood-CSF barrier function [4,
5, 6]
Dynamics of brain proteins in CSF [6, 7]
Theoretical background of neurochemical methods [8]
Reibergram: construction [9a]
and interpretation [9b]
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Laboratory practice
Proteinanalysis in Neurochemistry laboratory [10]
Cytology [11]
Neuroimmunology [12, 15,
39]
Oligoclonal IgG [13, 15,
30, 41]
Antibody detection, Antibody-Index [14,
15, 27,
39]
CSF Report [3, 16, 17],
Example of CSF data report [16, 18],
Laboratory Software: www.wormek.de, www.Comed-com.de
Particular Proteins
•
Neuron-spezific enolase [6, 7,
20, 21]
•
Tau protein [6, 7, 22]
•
Beta-trace protein [23, 24]
•
Carcinoembryonic antigen [25]
Clinical Interpretations
CSF data interpretations- Differentialdiagnosis of Neurological
diseases [15, 16,
17]
Multiple sclerosis [18, 6, 27, 39]
Tuberkulosis [1,
2, 29]
HIV and opportunistic diseases [1,
2, 16]
Neuroborreliosis [28]
Bacterial meningitis [1,
2, 16]
HSV Encephalitis [1,
2, 16]
CSF Analysis in tropical Neurology
•
Trypanosomiasis [29, 30]
•
Eosinophilic Meningitis [31]
• HIV and opportunistic infections [1,
2, 13]
• Tuberculosis [1,
2, 13, 19]
•
Viral Infektions [ 32, 33, 34, 35]
Quality Assessment
International consensus [36]
CSF Survey [36,
37] www.dgln.de
Actual CSF Survey: www.INSTAND-ev.de
Recommendations [38]
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